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Giovanni Appendino, Ph.D.

image of appendino

(as of March 22, 2017)

H-Index: 43
Peer-reviewed articles published: 383
Patents: 15
Number of citations: 5,616

Giovanni Appendino, Ph.D.

Giovanni Appendino was born in Carmagnola (TO), September 1, 1955 and graduated at the University of Torino in 1979.

In 1983 he was a University Lecturer at the University of Torino, and in 1998 became a University Lecturer. Since 2000 he has been a Full Professor at the Università del Piemonte Orientale, Department of Pharmaceutical Sciences. In 1985 he was a visiting scientist at the University of Gent, Belgium (Laboratory of Organic Synthesis, Prof. Pierre De Clercq).

He is Editor-in-Cief of the  Journal Fitoterapia and is a member of the Advisory Board of Natural Products Reports, Progress in the Chemistry of Organic Natural Products, Phytochemistry Letters, Natural Products Communications and PharmaNutrition. He is also a member of the Accademia di Agricoltura di Torino in Italy.

The research activity of Prof. Appendino takes inspiration from natural products to solve problems in organic chemistry (new synthetic methodologies), cell biology (novel mechanisms of activity), and medicine (new drug leads).

The following lines of research are currently pursued:

Secondary metabolites from edible plants and spices: identification of neutraceutical agents from local food plants.

Brain lipidomics: identification, synthesis and chemical modification of bioactive endolipids (endocannabinoids, endovanilloids, endogenous eicosanoids) and their natural products mimics (cannabinoids, capsaicinoids)
Sensory chemoreception: Synthesis of molecular probes to explore various classes of TRP-(TRPV1, TRPM8, TRPA1, TRPV4) and bitter (hTAS2R family) receptors, and their pharmacological exploitation.

Anticancer and antiviral chemotherapy: Synthesis of molecules aimed at various oncological end-points (tubulin, PgP, NF-B, PKC) and at achieving HIV de-latentization (phorboids).

Non-steroid hormonal agents: Identification of non-steroid natural products interacting with estrogen- and progesterone receptors, and exploitation of their biomedical potential.

Synthetic methodologies: chemoselective modification of polyfunctional compounds (polyphenolics, phenolic alcohols, phenolic amines). Development of new protocols of functional group modification.

Bioprospecting: secondary metabolites from niche area (Sardinia, Mediterranean Alps) and from medicinal plants.

Prof. Appendino has elucidated the structure of over 300 new natural products, and has published over 350 peer-reviewed articles and 13 book chapters on the chemistry and bioactivity of natural products. His distinctions include the Rhône-Poulenc Rorer Award of the Phytochemical Society of Europe for his studies on terpenoids (1991), the Quilico Medal of the Italian Chemical Society for his studies on bioactive natural products (2009), and the Bruker Prize of the Phytochemical Society of Europe in 2014. Prof. Appendino has acted as local coordinator of five EU research project cantered on natural products, and several national programs on bioactive natural products.